The Importance of Skin Irritation Testing in Cell Factories
As a kind of cell culture vessel with multi-layer structure, cell factories are widely used for large-scale cell culture, providing solid support for scientific research.However, how to ensure the quality of these cell factories, especially the safety of their materials, has become a problem we must face.
As a kind of cell culture vessel with multi-layer structure, cell factories are widely used for large-scale cell culture, providing solid support for scientific research.However, how to ensure the quality of these cell factories, especially the safety of their materials, has become a problem we must face.
Skin irritation test, as an important means of evaluating the safety of cell factory materials, plays a crucial role. This test evaluates the potential of a material to produce a skin irritation reaction by simulating skin contact under experimental conditions, thus ensuring the safe use of the material. In accordance with international and national standards such as ISO 10993-10-2010 and GB/T 16886/10-2017, the skin irritation test uses an animal intradermal irritation test, in which the reaction of the skin of rabbits is observed through intradermal injection of an extract.
In the test, we leach the samples from the cell factory in a specific solvent, and then inject the leachate into the skin of rabbits.After a certain period of time, we can clearly see the skin reactions such as erythema and oedema, so that we can determine whether the material contains any risk of causing skin irritation reactions.
The skin irritation test of the cell factory is not only a strict control of product quality, but also a responsibility to researchers and experimental animals. Through this test, we can ensure that the materials used in our cell factories are safe, non-toxic and will not adversely affect cell growth.At the same time, this also provides a strong guarantee for the smooth running of cell culture experiments.
Inactivated vaccines, on the other hand, are stored at low temperatures and do not need to be sterilised at high temperatures, so plastic materials such as polypropylene or polyethylene are often used.Selection of appropriate packaging materials can effectively maintain the stability and safety of vaccines, prolonging the shelf life of vaccines.
Only products that have been rigorously tested can provide us with reliable experimental support and promote the continuous progress of scientific research.