Cell Factory Tandem Operation Guide

As biopharmaceutical and cell culture technologies continue to evolve, cell factories are becoming a key tool in industrialised production. 

As biopharmaceutical and cell culture technologies continue to evolve, cell factories are becoming a key tool in industrialised production. 

However, traditional single-operation cell factories face long operating times and high risk of contamination. Tandem operation offers an innovative solution to this challenge.

Tandem operation reduces the risk of exogenous contamination by connecting multiple cell factories into a closed system, reducing the number of frequent lid openings.At the same time, tandem operation greatly improves productivity by allowing users to easily transfer liquids and perfuse media between multiple plants, shortening the operating time of a single plant.

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Tandem operation is simple. First, sterilise with alcohol and operate in a sterile environment.Then, accessories such as gas conversion kits and liquid transfer kits are installed, and a hose system is used to connect multiple plants in series to ensure uniform media supply by controlling the liquid flow rate with a peristaltic pump. The hose clamps are rationally adjusted to ensure that the liquid enters each plant at the same rate, and finally the culture environment is kept stable by venting and exhausting through the gas conversion system.

The airtightness and automation of this system greatly reduces operator involvement, thereby reducing the risk of human error.For large-scale manufacturers, reduced operating time and increased efficiency mean faster response to market demand, higher throughput, and an uncontaminated production process that safeguards product quality and safety.

Tandem operation of cellular factories offers significant production benefits for biopharmaceuticals, cell cultures and other fields, not only improving production efficiency, but also effectively reducing risk and improving product quality, making them ideal for companies looking to optimise their production processes.